Immunology of psoriasis
MA Lowes, M Suarez-Farinas… - Annual review of …, 2014 - annualreviews.org
The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The
reaction of these components to injury allows an effective cutaneous response to restore
homeostasis. Psoriasis vulgaris is the best-understood and most accessible human disease
that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-
23 and IL-12 to activate IL-17-producing T cells, Th1 cells, and Th22 cells to produce …
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The
reaction of these components to injury allows an effective cutaneous response to restore
homeostasis. Psoriasis vulgaris is the best-understood and most accessible human disease
that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-
23 and IL-12 to activate IL-17-producing T cells, Th1 cells, and Th22 cells to produce …