As CKD continues to increase worldwide, along with the demand for related life-saving
therapies, the financial burden of CKD will place an increasing drain on health care systems.
Experimental studies showed that glomerular capillary hypertension and impaired sieving
function with consequent protein overload play a pathogenic role in the progression of CKD.
Consistently, human studies show that proteinuria is an independent predictor of
progression and that its reduction is renoprotective. At comparable BP control, inhibitors of …