SGLT2 inhibition in the diabetic kidney—from mechanisms to clinical outcome
EJM van Bommel, MHA Muskiet… - Clinical Journal of the …, 2017 - journals.lww.com
Diabetic kidney disease not only has become the leading cause for ESRD worldwide but
also, highly contributes to increased cardiovascular morbidity and mortality in type 2
diabetes. Despite increased efforts to optimize renal and cardiovascular risk factors, like
hyperglycemia, hypertension, obesity, and dyslipidemia, they are often insufficiently
controlled in clinical practice. Although current drug interventions mostly target a single risk
factor, more substantial improvements of renal and cardiovascular outcomes can be …
also, highly contributes to increased cardiovascular morbidity and mortality in type 2
diabetes. Despite increased efforts to optimize renal and cardiovascular risk factors, like
hyperglycemia, hypertension, obesity, and dyslipidemia, they are often insufficiently
controlled in clinical practice. Although current drug interventions mostly target a single risk
factor, more substantial improvements of renal and cardiovascular outcomes can be …