[HTML][HTML] Defining and characterizing the progression of type 2 diabetes
VA Fonseca - Diabetes care, 2009 - ncbi.nlm.nih.gov
VA Fonseca
Diabetes care, 2009•ncbi.nlm.nih.govType 2 diabetes is a progressive dis-ease in which the risks of myocardial infarction, stroke,
microvascular events, and mortality are all strongly associated with hyperglycemia (1). The
disease course is primarily characterized by a decline in-cell function and worsening of
insulin resistance. The process is manifested clinically by deteriorations in multiple
parameters, including A1C, fasting plasma glucose (FPG), and postprandial glucose levels.
In this review, we will evaluate our current understanding of the role played by deteriorating …
microvascular events, and mortality are all strongly associated with hyperglycemia (1). The
disease course is primarily characterized by a decline in-cell function and worsening of
insulin resistance. The process is manifested clinically by deteriorations in multiple
parameters, including A1C, fasting plasma glucose (FPG), and postprandial glucose levels.
In this review, we will evaluate our current understanding of the role played by deteriorating …
Type 2 diabetes is a progressive dis-ease in which the risks of myocardial infarction, stroke, microvascular events, and mortality are all strongly associated with hyperglycemia (1). The disease course is primarily characterized by a decline in-cell function and worsening of insulin resistance. The process is manifested clinically by deteriorations in multiple parameters, including A1C, fasting plasma glucose (FPG), and postprandial glucose levels.
In this review, we will evaluate our current understanding of the role played by deteriorating-cell function and other abnormalities linked with the progression of type 2 diabetes. An improved understanding of these abnormalities may provide the scientific groundwork for novel therapies that may help achieve and maintain good glycemic control.
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