[HTML][HTML] The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis

Y Xie, R Chen, X Zhang, P Chen, X Liu, Y Xie, Y Yu… - Virology, 2011 - Elsevier
Y Xie, R Chen, X Zhang, P Chen, X Liu, Y Xie, Y Yu, Y Yang, Y Zou, J Ge, H Chen
Virology, 2011Elsevier
IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the
pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were
altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions
on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-
related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic
Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using …
IL-17-producing (Th17) and regulatory T (Treg) cells have been well established in the pathogenesis of many inflammatory diseases. To assess whether Th17 and Treg were altered in acute virus-induced myocarditis (AVMC) mice, we assessed Th17/Treg functions on different levels in AVMC. It was shown that the expression of splenic Th17 cells and Th17-related cytokines (IL-17A, IL-21) markedly increased. Interestingly, the expression of splenic Treg cells and Treg-related cytokines (TGF-β, IL-10) also significantly increased. Using neutralization of IL-17 in the AVMC, we found that Treg cells roughly decreased compared with isotype control mice. However, T cells and perforin dramatically increased, followed by a marked reduction in CVB3 replication. The results suggested that Th17 cells possibly contributed to viral replication through the action of Treg cells in mediating T cells and perforin response in AVMC.
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