Molecular regulation of hepatic dendritic cell function and its relation to liver transplant outcome

TL Sumpter, JG Lunz III, AJ Demetris… - Transplantation, 2009 - journals.lww.com
TL Sumpter, JG Lunz III, AJ Demetris, AW Thomson
Transplantation, 2009journals.lww.com
Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of
these important antigen-presenting cells may be suppressed by continual exposure to
microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is
emerging for a role of specific intracellular regulators of signal transduction and of cytokines
in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC.
Analysis of signaling molecule expression within DC in liver transplant tissue is likely to …
Abstract
Studies on liver interstitial dendritic cells (DC) indicate that the maturation and function of these important antigen-presenting cells may be suppressed by continual exposure to microbial products from the gut, in particular, bacterial lipopolysaccharide. New evidence is emerging for a role of specific intracellular regulators of signal transduction and of cytokines in the hepatic microenvironment, which may contribute to a hyporesponsive state in liver DC. Analysis of signaling molecule expression within DC in liver transplant tissue is likely to uncover its relation to allograft outcome.
Lippincott Williams & Wilkins