Histone deacetylase 1 (HDAC1) negatively regulates thermogenic program in brown adipocytes via coordinated regulation of histone H3 lysine 27 (H3K27) …
Inhibiting class I histone deacetylases (HDACs) increases energy expenditure, reduces
adiposity, and improves insulin sensitivity in obese mice. However, the precise mechanism
is poorly understood. Here, we demonstrate that HDAC1 is a negative regulator of the brown
adipocyte thermogenic program. The Hdac1 level is lower in mouse brown fat (BAT) than
white fat, is suppressed in mouse BAT during cold exposure or β 3-adrenergic stimulation,
and is down-regulated during brown adipocyte differentiation. Remarkably, overexpressing …
adiposity, and improves insulin sensitivity in obese mice. However, the precise mechanism
is poorly understood. Here, we demonstrate that HDAC1 is a negative regulator of the brown
adipocyte thermogenic program. The Hdac1 level is lower in mouse brown fat (BAT) than
white fat, is suppressed in mouse BAT during cold exposure or β 3-adrenergic stimulation,
and is down-regulated during brown adipocyte differentiation. Remarkably, overexpressing …
