Association of perivascular localization of aquaporin-4 with cognition and Alzheimer disease in aging brains
DM Zeppenfeld, M Simon, JD Haswell… - JAMA …, 2017 - jamanetwork.com
Importance Cognitive impairment and dementia, including Alzheimer disease (AD), are
common within the aging population, yet the factors that render the aging brain vulnerable to
these processes are unknown. Perivascular localization of aquaporin-4 (AQP4) facilitates
the clearance of interstitial solutes, including amyloid-β, through the brainwide network of
perivascular pathways termed theglymphatic system, which may be compromised in the
aging brain. Objectives To determine whether alterations in AQP4 expression or loss of …
common within the aging population, yet the factors that render the aging brain vulnerable to
these processes are unknown. Perivascular localization of aquaporin-4 (AQP4) facilitates
the clearance of interstitial solutes, including amyloid-β, through the brainwide network of
perivascular pathways termed theglymphatic system, which may be compromised in the
aging brain. Objectives To determine whether alterations in AQP4 expression or loss of …
