Electrolytic inferior vena cava model (EIM) of venous thrombosis

JA Diaz, SK Wrobleski, AE Hawley… - JoVE (Journal of …, 2011 - jove.com
Animal models serve a vital role in deep venous thrombosis (DVT) research in order to study
thrombus formation, thrombus resolution and to test potential therapeutic compounds (1).
New compounds to be utilized in the treatment and prevention of DVT are currently being
developed. The delivery of potential therapeutic antagonist compounds to an affected
thrombosed vein has been problematic. In the context of therapeutic applications, a model
that uses partial stasis and consistently generates thrombi within a major vein has been …