[HTML][HTML] NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response

TF Liu, VT Vachharajani, BK Yoza… - Journal of biological …, 2012 - ASBMB
Background: Switching from the acute early initiation to late adaptation response after TLR4
stimulation depends on SirT1. Results: Switching from glucose to fatty acid oxidation
between initiation and adaptation responses requires SirT6 and SirT1. Conclusion:
Bioenergy integrates metabolism and acute inflammation. Significance: Understanding
bioenergy shifts during inflammation may enable development of new therapies.