Identification and profiling of specialized pro-resolving mediators in human tears by lipid mediator metabolomics

JT English, PC Norris, RR Hodges, DA Dartt… - … and Essential Fatty …, 2017 - Elsevier
Specialized pro-resolving mediators (SPM), eg Resolvin D1, Protectin D1, Lipoxin A₄, and
Resolvin E1 have each shown to be active in ocular models reducing inflammation. In
general, SPMs have specific agonist functions that stimulate resolution of infection and
inflammation in animal disease models. The presence and quantity of SPM in human
emotional tears is of interest. Here, utilizing a targeted LC-MS-MS metabololipidomics based
approach we document the identification of pro-inflammatory (Prostaglandins and …