Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

C Franceschi, J Campisi - Journals of Gerontology Series A …, 2014 - academic.oup.com
C Franceschi, J Campisi
Journals of Gerontology Series A: Biomedical Sciences and Medical …, 2014academic.oup.com
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both
morbidity and mortality in the elderly people, as most if not all age-related diseases share an
inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its
potential causal role in contributing to adverse health outcomes remain largely unknown.
The identification of pathways that control age-related inflammation across multiple systems …
Abstract
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown. The identification of pathways that control age-related inflammation across multiple systems is therefore important in order to understand whether treatments that modulate inflammaging may be beneficial in old people. The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging. This article reports the main outcomes of this session.
Oxford University Press