Existing and emerging therapies for managing constipation and diarrhea
AE Bharucha, MM Wouters, J Tack - Current opinion in pharmacology, 2017 - Elsevier
Highlights•For constipation and diarrhea, stepwise therapy is recommended.•When initial
therapy is unsuccessful:•Secretagogues and 5-HT 4 receptor agonists are used for chronic
constipation.•Bile-acid binding agents, eluxadoline, and rifaximin are used to treat
diarrhea.•Several newer compounds are being developed and tested in clinical
trials.Functional bowel disorders (ie, constipation and diarrhea) are characterized by
abdominal pain, bloating, distention, and/or bowel habit abnormalities in the absence of …
therapy is unsuccessful:•Secretagogues and 5-HT 4 receptor agonists are used for chronic
constipation.•Bile-acid binding agents, eluxadoline, and rifaximin are used to treat
diarrhea.•Several newer compounds are being developed and tested in clinical
trials.Functional bowel disorders (ie, constipation and diarrhea) are characterized by
abdominal pain, bloating, distention, and/or bowel habit abnormalities in the absence of …
