Small-molecule inhibitors of pendrin potentiate the diuretic action of furosemide
O Cil, PM Haggie, P Phuan, JA Tan… - Journal of the American …, 2016 - journals.lww.com
Pendrin is a Cl−/HCO 3− exchanger expressed in type B and non-A, non-B intercalated cells
in the distal nephron, where it facilitates Cl− absorption and is involved in Na+ absorption
and acid-base balance. Pendrin-knockout mice show no fluid-electrolyte abnormalities
under baseline conditions, although mice with double knockout of pendrin and the Na+/Cl−
cotransporter (NCC) manifest profound salt wasting. Thus, pendrin may attenuate diuretic-
induced salt loss, but this function remains unconfirmed. To clarify the physiologic role of …
in the distal nephron, where it facilitates Cl− absorption and is involved in Na+ absorption
and acid-base balance. Pendrin-knockout mice show no fluid-electrolyte abnormalities
under baseline conditions, although mice with double knockout of pendrin and the Na+/Cl−
cotransporter (NCC) manifest profound salt wasting. Thus, pendrin may attenuate diuretic-
induced salt loss, but this function remains unconfirmed. To clarify the physiologic role of …