The role of pendrin in renal physiology
SM Wall, Y Lazo-Fernandez - Annual review of physiology, 2015 - annualreviews.org
Pendrin is a Na+-independent Cl−/HCO3− exchanger that localizes to type B and non-A,
non-B intercalated cells, which are expressed within the aldosterone-sensitive region of the
nephron, ie, the distal convoluted tubule, the connecting tubule, and the cortical collecting
duct. Type B cells mediate Cl− absorption and HCO3− secretion primarily through pendrin-
mediated Cl−/HCO3− exchange. At least in some treatment models, pendrin acts in tandem
with the Na+-dependent Cl−/HCO3− exchanger (NDCBE) encoded by Slc4a8 to mediate …
non-B intercalated cells, which are expressed within the aldosterone-sensitive region of the
nephron, ie, the distal convoluted tubule, the connecting tubule, and the cortical collecting
duct. Type B cells mediate Cl− absorption and HCO3− secretion primarily through pendrin-
mediated Cl−/HCO3− exchange. At least in some treatment models, pendrin acts in tandem
with the Na+-dependent Cl−/HCO3− exchanger (NDCBE) encoded by Slc4a8 to mediate …