[HTML][HTML] Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice
T Komori, M Tanaka, E Senba, A Miyajima… - Journal of Biological …, 2014 - ASBMB
Oncostatin M (OSM) belongs to the IL-6 family of cytokines and has diverse biological
effects, including the modulation of inflammatory responses. In the present study we
analyzed the roles of OSM signaling in obesity and related metabolic disorders. Under a
high-fat diet condition, OSM receptor β subunit-deficient (OSMRβ−/−) mice exhibited
increases in body weight and food intake compared with those observed in WT mice. In
addition, adipose tissue inflammation, insulin resistance, and hepatic steatosis were more …
effects, including the modulation of inflammatory responses. In the present study we
analyzed the roles of OSM signaling in obesity and related metabolic disorders. Under a
high-fat diet condition, OSM receptor β subunit-deficient (OSMRβ−/−) mice exhibited
increases in body weight and food intake compared with those observed in WT mice. In
addition, adipose tissue inflammation, insulin resistance, and hepatic steatosis were more …