[HTML][HTML] Impaired nutrient signaling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse
A Bröer, T Juelich, JM Vanslambrouck, N Tietze… - Journal of Biological …, 2011 - ASBMB
Amino acid uptake in the intestine and kidney is mediated by a variety of amino acid
transporters. To understand the role of epithelial neutral amino acid uptake in whole body
homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0) amino acid
transporter B 0 AT1 (Slc6a19). A general neutral aminoaciduria was observed similar to
human Hartnup disorder which is caused by mutations in SLC6A19. Na+-dependent uptake
of neutral amino acids into the intestine and renal brush-border membrane vesicles was …
transporters. To understand the role of epithelial neutral amino acid uptake in whole body
homeostasis, we analyzed mice lacking the apical broad-spectrum neutral (0) amino acid
transporter B 0 AT1 (Slc6a19). A general neutral aminoaciduria was observed similar to
human Hartnup disorder which is caused by mutations in SLC6A19. Na+-dependent uptake
of neutral amino acids into the intestine and renal brush-border membrane vesicles was …