Selectivity of BI 689648, a novel, highly selective aldosterone synthase inhibitor: comparison with FAD286 and LCI699 in nonhuman primates
SM Weldon, MA Cerny, K Gueneva-Boucheva… - The Journal of …, 2016 - Elsevier
The mineralocorticoid aldosterone is an important regulator of blood pressure, volume, and
electrolyte balance. However, excess aldosterone can be deleterious as a driver of vascular
remodeling and tissue fibrosis associated with cardiometabolic diseases. Aldosterone
synthase (AS) inhibitors (ASI) attenuate the production of aldosterone directly and have
been proposed as an alternative to mineralocorticoid receptor antagonists for blocking the
pathologic effects of excess aldosterone. Discovery of selective ASIs has been challenging …
electrolyte balance. However, excess aldosterone can be deleterious as a driver of vascular
remodeling and tissue fibrosis associated with cardiometabolic diseases. Aldosterone
synthase (AS) inhibitors (ASI) attenuate the production of aldosterone directly and have
been proposed as an alternative to mineralocorticoid receptor antagonists for blocking the
pathologic effects of excess aldosterone. Discovery of selective ASIs has been challenging …
