The interaction of versican with its binding partners

YJ Wu, DPLA PIERRE, J Wu, AJ Yee, BB Yang - Cell research, 2005 - nature.com
YJ Wu, DPLA PIERRE, J Wu, AJ Yee, BB Yang
Cell research, 2005nature.com
Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans
located primarily within the extracellular matrix (ECM). Versican, like other members of its
family, has unique N-and C-terminal globular regions, each with multiple motifs. A large
glycosaminoglycan-binding region lies between them. This review will begin by outlining
these structures, in the context of ECM proteoglycans. The diverse binding partners afforded
to versican by virtue of its modular design will then be examined. These include ECM …
Abstract
Versican belongs to the family of the large aggregating chondroitin sulfate proteoglycans located primarily within the extracellular matrix (ECM). Versican, like other members of its family, has unique N-and C-terminal globular regions, each with multiple motifs. A large glycosaminoglycan-binding region lies between them. This review will begin by outlining these structures, in the context of ECM proteoglycans. The diverse binding partners afforded to versican by virtue of its modular design will then be examined. These include ECM components, such as hyaluronan, type I collagen, tenascin-R, fibulin-1, and-2, fibrillin-1, fibronectin, P-and L-selectins, and chemokines. Versican also binds to the cell surface proteins CD44, integrin β1, epidermal growth factor receptor, and P-selectin glycoprotein ligand-1. These multiple interactors play important roles in cell behaviour, and the roles of versican in modulating such processes are discussed.
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