Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor β (TGFβ)-, epidermal growth factor (EGF)-, and nuclear factor κB (NFκB) …
I Kang, DW Yoon, KR Braun, TN Wight - Journal of Biological Chemistry, 2014 - jbc.org
Monocyte/macrophage accumulation plays a critical role during progression of
cardiovascular diseases, such as atherosclerosis. Our previous studies demonstrated that
retrovirally mediated expression of the versican V3 splice variant (V3) by arterial smooth
muscle cells (ASMCs) decreases monocyte adhesion in vitro and macrophage accumulation
in a model of lipid-induced neointimal formation in vivo. We now demonstrate that V3-
expressing ASMCs resist monocyte adhesion by altering the composition of the …
cardiovascular diseases, such as atherosclerosis. Our previous studies demonstrated that
retrovirally mediated expression of the versican V3 splice variant (V3) by arterial smooth
muscle cells (ASMCs) decreases monocyte adhesion in vitro and macrophage accumulation
in a model of lipid-induced neointimal formation in vivo. We now demonstrate that V3-
expressing ASMCs resist monocyte adhesion by altering the composition of the …