The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades
A Tugores, J Le, I Sorokina, AJ Snijders… - Journal of Biological …, 2001 - jbc.org
Exon trapping and cDNA selection procedures were used to search for novel genes at
human chromosome 11p13, a region previously associated with loss of heterozygosity in
epithelial carcinomas. Using these approaches, we found the ESE-2 and ESE-3 genes,
coding for ETS domain-containing transcription factors. These genes lie in close proximity to
the catalase gene within a∼ 200-kilobase genomic interval. ESE-3 mRNA is widely
expressed in human tissues with high epithelial content, and immunohistochemical analysis …
human chromosome 11p13, a region previously associated with loss of heterozygosity in
epithelial carcinomas. Using these approaches, we found the ESE-2 and ESE-3 genes,
coding for ETS domain-containing transcription factors. These genes lie in close proximity to
the catalase gene within a∼ 200-kilobase genomic interval. ESE-3 mRNA is widely
expressed in human tissues with high epithelial content, and immunohistochemical analysis …