Follistatin-like protein-1 is a novel proinflammatory molecule
T Miyamae, AD Marinov, D Sowders… - The Journal of …, 2006 - journals.aai.org
T Miyamae, AD Marinov, D Sowders, DC Wilson, J Devlin, R Boudreau, P Robbins, R Hirsch
The Journal of Immunology, 2006•journals.aai.orgWhile analyzing gene expression in collagen-induced arthritis, we discovered that a poorly
characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse
paws during early arthritis, especially at the interface of synovial pannus and eroding bone.
In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously
unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts
leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6 …
characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse
paws during early arthritis, especially at the interface of synovial pannus and eroding bone.
In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously
unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts
leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6 …
Abstract
While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.
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