Background Current treatment modalities in squamous cell carcinoma of the head and neck
have failed to improve survival. Advances in the discovery of novel biomarkers and targets
for therapy are necessary. Design Differential display and microarray analysis were used to
identify differences in gene expression between squamous carcinoma and matched
nonmalignant biopsy specimens. Differences in gene expression found in vivo were also
tested in vitro by comparing primary cultured normal oral epithelium with head and neck …