Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors
Interfering with Ets transcription factor function reverses multiple aspects of the transformed
phenotype of mouse or human tumor cells. However, the unknown number of individual Ets
factors expressed in any cellular context and the similar DNA binding specificities of Ets
family members complicates the identification of those that mediate transformation. By
utilizing quantitative PCR assays for 25 mouse Ets factors, we analyzed the expression of
essentially the entire Ets family in normal mammary tissue, mammary-related cell lines, and …
phenotype of mouse or human tumor cells. However, the unknown number of individual Ets
factors expressed in any cellular context and the similar DNA binding specificities of Ets
family members complicates the identification of those that mediate transformation. By
utilizing quantitative PCR assays for 25 mouse Ets factors, we analyzed the expression of
essentially the entire Ets family in normal mammary tissue, mammary-related cell lines, and …
