Wnt signaling in liver fibrosis: progress, challenges and potential directions

C Miao, Y Yang, X He, C Huang, Y Huang, L Zhang… - Biochimie, 2013 - Elsevier
Liver fibrosis is a common wound-healing response to chronic liver injuries, including
alcoholic or drug toxicity, persistent viral infection, and genetic factors. Myofibroblastic
transdifferentiation (MTD) is the pivotal event during liver fibrogenesis, and research in the
past few years has identified key mediators and molecular mechanisms responsible for MTD
of hepatic stellate cells (HSCs). HSCs are undifferentiated cells which play an important role
in liver regeneration. Recent evidence demonstrates that HSCs derive from mesoderm and …