Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of
Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates
cardinal features of the disease: an age-dependent and levodopa-responsive slowness of
movement associated with diminished dopamine release and axonal pathology of
nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's
disease and are a resource for the investigation of pathogenesis and therapeutics.