[HTML][HTML] Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain-and dynamin-dependent endocytosis and …
S Salinas, C Zussy, F Loustalot, D Henaff… - Journal of Biological …, 2014 - ASBMB
The coxsackievirus and adenovirus receptor (CAR) serves as a docking factor for some
adenovirus (AdV) types and group B coxsackieviruses. Its role in AdV internalization is
unclear as studies suggest that its intracellular domain is dispensable for some AdV
infection. We previously showed that in motor neurons, AdV induced CAR internalization
and co-transport in axons, suggesting that CAR was linked to endocytic and long-range
transport machineries. Here, we characterized the mechanisms of CAR endocytosis in …
adenovirus (AdV) types and group B coxsackieviruses. Its role in AdV internalization is
unclear as studies suggest that its intracellular domain is dispensable for some AdV
infection. We previously showed that in motor neurons, AdV induced CAR internalization
and co-transport in axons, suggesting that CAR was linked to endocytic and long-range
transport machineries. Here, we characterized the mechanisms of CAR endocytosis in …