CAV-2—why a canine virus is a neurobiologist's best friend

F Junyent, EJ Kremer - Current opinion in pharmacology, 2015 - Elsevier
Highlights•CAV-2 vectors preferentially transduce neurons in rodents and
primates.•Retrograde axonal transport leads to widespread biodistribution in the brain
parenchyma.•Helper-dependent CAV-2 vector treat global brain pathology in MPS
brain.•Use of CAV-2 vector for fundamental neurobiology is going viral.Canine adenovirus
type 2 (CAV-2) vectors are powerful tools for fundamental and applied neurobiology due to
their negligible immunogenicity, preferential transduction of neurons, widespread …