High expression of FOXP3 in primary melanoma is associated with tumour progression
AL Gerber, A Münst, C Schlapbach… - British journal of …, 2014 - academic.oup.com
AL Gerber, A Münst, C Schlapbach, M Shafighi, D Kiermeir, R Hüsler, RE Hunger
British journal of dermatology, 2014•academic.oup.comBackground The antitumour immune response plays an important role in the prognosis of
melanoma. High numbers of circulating regulatory T cells have been associated with rapid
disease progression. Objectives To assess the influence of forkhead box protein (FOXP) 3,
CD1a and langerin expression on the prognosis of primary melanoma. Methods We
analysed 185 primary melanomas by immunohistochemical staining for expression of the
regulatory T‐cell marker FOXP3 and the dendritic cell markers langerin and CD1a, and …
melanoma. High numbers of circulating regulatory T cells have been associated with rapid
disease progression. Objectives To assess the influence of forkhead box protein (FOXP) 3,
CD1a and langerin expression on the prognosis of primary melanoma. Methods We
analysed 185 primary melanomas by immunohistochemical staining for expression of the
regulatory T‐cell marker FOXP3 and the dendritic cell markers langerin and CD1a, and …
Background
The antitumour immune response plays an important role in the prognosis of melanoma. High numbers of circulating regulatory T cells have been associated with rapid disease progression.
Objectives
To assess the influence of forkhead box protein (FOXP)3, CD1a and langerin expression on the prognosis of primary melanoma.
Methods
We analysed 185 primary melanomas by immunohistochemical staining for expression of the regulatory T‐cell marker FOXP3 and the dendritic cell markers langerin and CD1a, and correlated marker expression with clinical outcome.
Results
Disease‐free survival and overall survival were significantly longer in patients expressing low levels of FOXP3 in the primary melanoma, whereas they were associated with high expression of CD1a. The negative prognostic value of FOXP3 expression was independent of the Breslow tumour thickness. Langerin expression did not correlate with the clinical outcome.
Conclusions
High expression of FOXP3 in the primary melanoma may be used as an additional independent prognostic marker for early tumour progression in patients with melanoma.
Oxford University Press