Treg stability: to be or not to be
AE Overacre, DAA Vignali - Current opinion in immunology, 2016 - Elsevier
Current opinion in immunology, 2016•Elsevier
Highlights•T reg stability remains a controversial topic and thus requires further study.•T regs
can lose suppressive function while maintaining Foxp3 expression.•T reg stability
maintained in part by epigenetic modifications, FOXO, Eos and Nrp1.•T reg stability may be
therapeutically manipulated to treat cancer and autoimmunity.Regulatory T cell (T reg)
stability has been primarily determined by the maintained expression of the transcription
factor Forkhead box P3 (Foxp3). However, T regs can exhibit instability while maintaining …
can lose suppressive function while maintaining Foxp3 expression.•T reg stability
maintained in part by epigenetic modifications, FOXO, Eos and Nrp1.•T reg stability may be
therapeutically manipulated to treat cancer and autoimmunity.Regulatory T cell (T reg)
stability has been primarily determined by the maintained expression of the transcription
factor Forkhead box P3 (Foxp3). However, T regs can exhibit instability while maintaining …
Highlights
- T reg stability remains a controversial topic and thus requires further study.
- T regs can lose suppressive function while maintaining Foxp3 expression.
- T reg stability maintained in part by epigenetic modifications, FOXO, Eos and Nrp1.
- T reg stability may be therapeutically manipulated to treat cancer and autoimmunity.
Regulatory T cell (T reg) stability has been primarily determined by the maintained expression of the transcription factor Forkhead box P3 (Foxp3). However, T regs can exhibit instability while maintaining Foxp3 expression, requiring a re-examination of what defines T reg stability. Recent work suggests that the establishment and stability of T regs is mediated by a number of mechanisms besides Foxp3 expression, such as epigenetic modifications, Foxo1/3a localization, expression of Eos and signaling via Neuropilin-1. Additional studies may help to define approaches that can undermine T reg stability in cancer or enhance T reg stability in transplantation, autoimmune or inflammatory diseases and therefore have substantial therapeutic utility. In this review, we will discuss how T reg stability is defined and the mechanisms utilized to maintain stability.
Elsevier