Purpose To optimize the combination of ionizing radiation and cellular immunotherapy using
a preclinical autochthonous model of prostate cancer. Methods and Materials Transgenic
mice expressing a model antigen under a prostate-specific promoter were treated using a
platform that integrates cone-beam CT imaging with 3-dimensional conformal therapy. Using
this technology we investigated the immunologic and therapeutic effects of combining
ionizing radiation with granulocyte/macrophage colony-stimulating factor-secreting cellular …