The incidence and mortality rates of cutaneous melanoma continue to increase worldwide,
despite the deployment of targeted therapies. Recently, there has been rapid growth and
development in our understanding of epigenetic mechanisms and their role in cancer
pathobiology. Epigenetics—defined as the processes resulting in heritable changes in gene
expression beyond those caused by alterations in the DNA sequence—likely contain the
information that encodes for such phenotypic variation between individuals with identical …