[HTML][HTML] Elevated ST2 distinguishes incidences of pediatric heart and small bowel transplant rejection
LR Mathews, JM Lott, K Isse, A Lesniak… - American Journal of …, 2016 - Elsevier
Elevated serum soluble (s) suppressor of tumorigenicity-2 is observed during cardiovascular
and inflammatory bowel diseases. To ascertain whether modulated ST2 levels signify heart
(HTx) or small bowel transplant (SBTx) rejection, we quantified sST2 in serially obtained
pediatric HTx (n= 41) and SBTx recipient (n= 18) sera. At times of biopsy-diagnosed HTx
rejection (cellular and/or antibody-mediated), serum sST2 was elevated compared to
rejection-free time points (1714±329 vs. 546.5±141.6 pg/mL; p= 0.0002). SBTx recipients …
and inflammatory bowel diseases. To ascertain whether modulated ST2 levels signify heart
(HTx) or small bowel transplant (SBTx) rejection, we quantified sST2 in serially obtained
pediatric HTx (n= 41) and SBTx recipient (n= 18) sera. At times of biopsy-diagnosed HTx
rejection (cellular and/or antibody-mediated), serum sST2 was elevated compared to
rejection-free time points (1714±329 vs. 546.5±141.6 pg/mL; p= 0.0002). SBTx recipients …