[HTML][HTML] Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation
H Hayakawa, M Hayakawa, A Kume… - Journal of Biological …, 2007 - ASBMB
The ST2 gene produces a soluble secreted form and a transmembrane form, referred to as
soluble ST2 and ST2L, respectively. A recent study has reported that interleukin (IL)-33 is a
specific ligand of ST2L and induces production of T helper type 2 (Th2) cytokines. Although
soluble ST2 is highly produced in sera of asthmatic patients and plays a critical role for
production of Th2 cytokines, the function of soluble ST2 in relation to IL-33 signaling remains
unclear. Here we show antagonistic effects of soluble ST2 on IL-33 signaling using a murine …
soluble ST2 and ST2L, respectively. A recent study has reported that interleukin (IL)-33 is a
specific ligand of ST2L and induces production of T helper type 2 (Th2) cytokines. Although
soluble ST2 is highly produced in sera of asthmatic patients and plays a critical role for
production of Th2 cytokines, the function of soluble ST2 in relation to IL-33 signaling remains
unclear. Here we show antagonistic effects of soluble ST2 on IL-33 signaling using a murine …