Multiplex high-throughput gene mutation analysis in acute myeloid leukemia
J Dunlap, C Beadling, A Warrick, T Neff, WH Fleming… - Human pathology, 2012 - Elsevier
Classification of acute myeloid leukemia increasingly depends on genetic analysis.
However, the number of known mutations in acute myeloid leukemia is expanding rapidly.
Therefore, we tested a high-throughput screening method for acute myeloid leukemia
mutation analysis using a multiplex mass spectrometry–based approach. To our knowledge,
this is the first reported application of this approach to genotype leukemias in a clinical
setting. One hundred seven acute myeloid leukemia cases were screened for mutations …
However, the number of known mutations in acute myeloid leukemia is expanding rapidly.
Therefore, we tested a high-throughput screening method for acute myeloid leukemia
mutation analysis using a multiplex mass spectrometry–based approach. To our knowledge,
this is the first reported application of this approach to genotype leukemias in a clinical
setting. One hundred seven acute myeloid leukemia cases were screened for mutations …