Hepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters
G Martovetsky, JB Tee, SK Nigam - Molecular pharmacology, 2013 - Elsevier
The transcriptional regulation of drug-metabolizing enzymes and transporters (here
collectively referred to as DMEs) in the developing proximal tubule (PT) is not well
understood. As in the liver, DME regulation in the PT may be mediated through nuclear
receptors, which are thought to “sense” deviations from homeostasis by being activated by
ligands, some of which are handled by DMEs, including drug transporters. Systems analysis
of transcriptomic data during kidney development predicted a set of upstream transcription …
collectively referred to as DMEs) in the developing proximal tubule (PT) is not well
understood. As in the liver, DME regulation in the PT may be mediated through nuclear
receptors, which are thought to “sense” deviations from homeostasis by being activated by
ligands, some of which are handled by DMEs, including drug transporters. Systems analysis
of transcriptomic data during kidney development predicted a set of upstream transcription …
