Sex-specific basis of severe placental dysfunction leading to extreme preterm delivery
OBJECTIVES: Since pregnancies with a male fetus have higher perinatal complications
attributed to placental dysfunction, including severe pre-eclampsia and intrauterine growth
restriction, the objective of our study was to formally evaluate placental pathology for a
placental origin of these sex-specific differences. DESIGN: Retrospective study at Mount
Sinai Hospital in Toronto, Canada. Identification of 262 singleton pregnancies affected by
severe pre-eclampsia and/or intrauterine growth restriction who delivered between 22 and …
attributed to placental dysfunction, including severe pre-eclampsia and intrauterine growth
restriction, the objective of our study was to formally evaluate placental pathology for a
placental origin of these sex-specific differences. DESIGN: Retrospective study at Mount
Sinai Hospital in Toronto, Canada. Identification of 262 singleton pregnancies affected by
severe pre-eclampsia and/or intrauterine growth restriction who delivered between 22 and …