Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1
ZK Zsengellér, A Rajakumar, JT Hunter… - … An International Journal …, 2016 - Elsevier
Preeclampsia is a common medical complication of pregnancy that is associated with
significant morbidity and mortality to the mother and the baby. Extensive human
epidemiological and experimental studies suggest that excess placental soluble fms-like
tyrosine kinase 1, a potent anti-angiogenic factor leads to the maternal hypertension,
proteinuria and other systemic complications of preeclampsia. To evaluate the mechanisms
of the aberrant placental sFlt1 expression, we studied the role of mitochondrial dysfunction …
significant morbidity and mortality to the mother and the baby. Extensive human
epidemiological and experimental studies suggest that excess placental soluble fms-like
tyrosine kinase 1, a potent anti-angiogenic factor leads to the maternal hypertension,
proteinuria and other systemic complications of preeclampsia. To evaluate the mechanisms
of the aberrant placental sFlt1 expression, we studied the role of mitochondrial dysfunction …