Exposure to particulate matter (PM), a major component of air pollution, contributes to
increased morbidity and mortality worldwide. PM induces innate immune responses and
contributes to allergic sensitization, although the mechanisms governing this process remain
unclear. Lung mucosal uric acid has also been linked to allergic sensitization. The links
among PM exposure, uric acid, and allergic sensitization remain unexplored. We therefore
investigated the mechanisms behind PM-induced allergic sensitization in the context of lung …