Lymphotoxin and TNF: how it all began—a tribute to the travelers
NH Ruddle - Cytokine & growth factor reviews, 2014 - Elsevier
The journey from the discoveries of lymphotoxin (LT) and tumor necrosis factor (TNF) to the
present day age of cytokine inhibitors as therapeutics has been an exciting one with many
participants and highs and lows; the saga is compared to that in “The Wizard of Oz”. This
communication summarizes the contributions of key players in the discovery of the cytokines
and their receptors, the changes in nomenclature, and the discovery of the LT family's crucial
role in secondary and tertiary lymphoid organs. The remarkable advances in therapeutics …
present day age of cytokine inhibitors as therapeutics has been an exciting one with many
participants and highs and lows; the saga is compared to that in “The Wizard of Oz”. This
communication summarizes the contributions of key players in the discovery of the cytokines
and their receptors, the changes in nomenclature, and the discovery of the LT family's crucial
role in secondary and tertiary lymphoid organs. The remarkable advances in therapeutics …