Liver fibrosis results from chronic injury of hepatocytes and activation of Collagen Type I
producing myofibroblasts that produce fibrous scar in liver fibrosis. Myofibroblasts are not
present in the normal liver but rapidly appear early in experimental and clinical liver injury.
The origin of the myofibroblast in liver fibrosis is still unresolved. The possibilities include
activation of liver resident cells including portal fibroblasts, hepatic stellate cells,
mesenchymal progenitor cells, and fibrocytes recruited from the bone marrow. It is …