[PDF][PDF] Pharmacokinetics of heparin. II. Studies of time dependence in rats.
TD Bjornsson, G Levy - Journal of Pharmacology and Experimental …, 1979 - Citeseer
TD Bjornsson, G Levy
Journal of Pharmacology and Experimental Therapeutics, 1979•CiteseerMethods Male Sprague-Dawley rats (Blue Spruce Farms, Altamont, NY), weighing 257 to
375 g, were given unrestricted access to food (Charles River Formula 4RF) and water. A two-
piece cannula of silicone rubberpolyethylene was implanted in their right jugular and
femoral veins under ether anesthesia(Weeks and Davis, 1964). Injections of heparin
solutions and collections of blood samples were made through the jugular vein cannula,
whereas the infusions of heparin were administered through the femoral vein cannula. Each …
375 g, were given unrestricted access to food (Charles River Formula 4RF) and water. A two-
piece cannula of silicone rubberpolyethylene was implanted in their right jugular and
femoral veins under ether anesthesia(Weeks and Davis, 1964). Injections of heparin
solutions and collections of blood samples were made through the jugular vein cannula,
whereas the infusions of heparin were administered through the femoral vein cannula. Each …
Methods
Male Sprague-Dawley rats (Blue Spruce Farms, Altamont, NY), weighing 257 to 375 g, were given unrestricted access to food (Charles River Formula 4RF) and water. A two-piece cannula of silicone rubberpolyethylene was implanted in their right jugular and femoral veins under ether anesthesia(Weeks and Davis, 1964). Injections of heparin solutions and collections of blood samples were made through the jugular vein cannula, whereas the infusions of heparin were administered through the femoral vein cannula. Each rat received an iv bolus injection of 100 (rats 1 and 2) or 150 (rats 3 to 5) U of heparin. These doses, when normalized for body
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