Strategies for targeting protein–protein interactions with synthetic agents
H Yin, AD Hamilton - Angewandte Chemie International Edition, 2005 - Wiley Online Library
H Yin, AD Hamilton
Angewandte Chemie International Edition, 2005•Wiley Online LibraryThe development of small‐molecule modulators of protein–protein interactions is a
formidable goal, albeit one that possesses significant potential for the discovery of novel
therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition
of two large protein partners with low‐molecular‐weight ligands. This review discusses the
strategies for targeting protein–protein interactions and the state of the art in the rational
design of molecules that mimic the structures and functions of their natural targets.
formidable goal, albeit one that possesses significant potential for the discovery of novel
therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition
of two large protein partners with low‐molecular‐weight ligands. This review discusses the
strategies for targeting protein–protein interactions and the state of the art in the rational
design of molecules that mimic the structures and functions of their natural targets.
Abstract
The development of small‐molecule modulators of protein–protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low‐molecular‐weight ligands. This review discusses the strategies for targeting protein–protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.
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