Amphoterin is a protein enhancing process extension and migration in embryonic neurons
and in tumor cells through binding to receptor for advanced glycation end products (RAGE),
a multiligand transmembrane receptor. S100 proteins, especially S100B, are abundantly
expressed in the nervous system and are suggested to function as cytokines with both
neurotrophic and neurotoxic effects. However, the cell surface receptor for the cytokine
function of S100B has not been identified. Here we show that two S100 family proteins …