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Protection against preterm birth and fetal inflammatory injury
In this episode, Nardhy Gomez-Lopez explains that macrophages exert anti-inflammatory effects in late gestation, to maintain uterine quiescence and to protect against fetal inflammatory injury that compromises postnatal survival...
Published October 13, 2021
Author's Take
MLK3 mediation and the impact of PKG1α on cardiac function
In this episode, Robert Blanton explains how this paper identifies mixed lineage kinase 3 as a novel PKG1a substrate. MLK3 mediates PKGI therapeutic effects on LV function but regulates blood pressure independently of PKG1...
Published September 22, 2021
Author's Take
Antibodies to vaccine-preventable infections and CAR-T cell therapy
In this episode, Joshua Hill explains that they investigated antibodies to vaccine-preventable infections and other pathogen-specific antibodies in individuals with remission after CAR-T-cell therapy for B-lineage malignancies...
Published June 22, 2021
Author's Take
Regulation of human brown/beige adipocyte lipolysis and thermogenesis
In this episode, Cheryl Cero explains that β3-ARs in human brown/beige adipocytes are required to maintain multiple components of lipolytic and thermogenic cellular machinery and β3-AR agonists could be used to achieve metabolic benefit in humans...
Published June 18, 2021
Author's Take
Base editing in human primary muscle stem cells and mutation repair
In this episode, Helena Escobar and Simone Spuler explain that patient primary muscle stems cells gene repaired with greater than 90% efficiency by base editing maintain their regenerative properties...
Published May 28, 2021
Author's Take
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