Abstract
Authors
Nadir Yehya, Jacob E. Till, Nishi Srivastava, Donglan Zhang, Jason D. Christie, Erica L. Carpenter, Nilam S. Mangalmurti, Wanding Zhou
Figure 1
Comparing methylation (837 CpG probes) of isolated reference cells, ARDS, and controls.
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Myeloid cells dominate most profiles, with 2 distinct subgroups: a larger group with mainly granulocytes (potentially NETosis) and a smaller group enriched for monocyte. In 1 CART19-treated patient, a B cell cfDNA signal was observed, consistent with CART-19 targeting B cells. Several patients with ARDS and controls displayed signal from liver cells, suggesting liver damage. A neuron/glial cell signal was detected in 1 sample, potentially reflecting brain injury, and 1 sample exhibited a strong signal from erythrocyte progenitors.
