ResearchIn-Press PreviewAngiogenesisVascular biology
Open Access | 
10.1172/jci.insight.160372
Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers Cerebral cavernous malformation
Xi Yang,1 Shi-Ting Wu,1 Rui Gao,1 Rui Wang,1 Yixuan Wang,1 Zhenkun Dong,2 Lu Wang,1 Chunxiao Qi,1 Xiaohong Wang,3 M. Lienhard Schmitz,4 Renjing Liu,5 Zhiming Han,6 Lu Wang,2 and Xiangjian Zheng7
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by
Yang, X.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Wu, S. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Gao, R. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by
Wang, R.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Wang, Y. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Dong, Z. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Wang, L. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Qi, C. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by
Wang, X.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by
Schmitz, M.
in:
JCI
|
PubMed
|
Google Scholar
|
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Liu, R. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Han, Z. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by Wang, L. in: JCI | PubMed | Google Scholar
1Department of Pharmacology, Tianjin Medical University, Tianjin, China
2Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
3Laboratory of Molecular ophthalmology, Tianjin Medical University, Tianjin, China
4Institute of Biochemistry, Justus Liebig University, Giessen, Germany
5Vascular Epigenetic Laboratory, Victor Chang Cardiac Research Institute, Sydney, Australia
6State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
7Department of Pharmacology, Tianjin Medical Tianjin Medical University, Tianjin, China
Find articles by
Zheng, X.
in:
JCI
|
PubMed
|
Google Scholar
|
Published January 24, 2023 - More info
Copyright © 2023, Yang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
