TY - JOUR AU - Schuster, Daniel J. AU - Karuna, Shelly AU - Brackett, Caroline AU - Wesley, Martina AU - Li, Shuying S. AU - Eisel, Nathan AU - Tenney, DeAnna AU - Hilliard, Sir’Tauria AU - Yates, Nicole L. AU - Heptinstall, Jack R. AU - Williams, LaTonya D. AU - Shen, Xiaoying AU - Rolfe, Robert AU - Cabello, Robinson AU - Zhang, Lu AU - Sawant, Sheetal AU - Hu, Jiani AU - Randhawa, April Kaur AU - Hyrien, Ollivier AU - Hural, John A. AU - Corey, Lawrence AU - Frank, Ian AU - Tomaras, Georgia D. AU - Seaton, Kelly E. AU - , T1 - Lower SARS-CoV-2–specific humoral immunity in people living with HIV-1 recovered from nonhospitalized COVID-19 PY - 2022/11/08/ AB - People living with HIV-1 (PLWH) exhibit more rapid antibody decline following routine immunization and elevated baseline chronic inflammation than people without HIV-1 (PWOH), indicating potential for diminished humoral immunity during SARS-CoV-2 infection. Conflicting reports have emerged on the ability of PLWH to maintain humoral protection against SARS-CoV-2 coinfection during convalescence. It is unknown whether peak COVID-19 severity, along with HIV-1 infection status, associates with the quality and quantity of humoral immunity following recovery. Using a cross-sectional observational cohort from the United States and Peru, adults were enrolled 1–10 weeks after SARS-CoV-2 infection diagnosis or symptom resolution. Serum antibodies were analyzed for SARS-CoV-2–specific response rates, binding magnitudes, ACE2 receptor blocking, and antibody-dependent cellular phagocytosis. Overall, (a) PLWH exhibited a trend toward decreased magnitude of SARS-CoV-2–specific antibodies, despite modestly increased overall response rates when compared with PWOH; (b) PLWH recovered from symptomatic outpatient COVID-19 had comparatively diminished immune responses; and (c) PLWH lacked a corresponding increase in SARS-CoV-2 antibodies with increased COVID-19 severity when asymptomatic versus symptomatic outpatient disease was compared. JF - JCI Insight JA - JCI Insight SN - 2379-3708 DO - 10.1172/jci.insight.158402 VL - 7 IS - 21 UR - https://doi.org/10.1172/jci.insight.158402 PB - The American Society for Clinical Investigation ER -