TY - JOUR AU - Cimini, Maria AU - Garikipati, Venkata Naga Srikanth AU - de Lucia, Claudio AU - Cheng, Zhongjian AU - Wang, Chunlin AU - Truongcao, May M. AU - Lucchese, Anna Maria AU - Roy, Rajika AU - Benedict, Cindy AU - Goukassian, David A. AU - Koch, Walter J. AU - Kishore, Raj T1 - Podoplanin neutralization improves cardiac remodeling and function after myocardial infarction PY - 2019/08/08/ AB - Podoplanin (PDPN), a small mucin-type transmembrane glycoprotein, has been recently shown to be expressed by lymphangiogenic, fibrogenic, and mesenchymal progenitor cells in the acutely and chronically infarcted myocardium. PDPN binds to a C-type lectin–like receptor 2 highly expressed by CD11bhi cells following inflammatory stimuli. Why PDPN expression appears only after organ injury is currently unknown. Here, we characterize the role of PDPN in different stages of myocardial repair after infarction and propose a PDPN-mediated mechanism in the resolution of post–myocardial infarction (MI) inflammatory response and cardiac repair. Neutralization of PDPN led to significant improvements in the left ventricular (LV) functions and scar composition in animals treated with PDPN-neutralizing antibody. The inhibition of the interaction between PDPN and C-type lectin–like receptor 2 expressing immune cells in the heart enhances the cardiac performance, regeneration, and angiogenesis after MI. Our data indicate that modulating the interaction between PDPN-positive cells with the immune cells after MI positively affects immune cell recruitment and may represent a novel therapeutic target to augment post-MI cardiac repair, regeneration, and function. JF - JCI Insight JA - JCI Insight SN - 2379-3708 DO - 10.1172/jci.insight.126967 VL - 4 IS - 15 UR - https://doi.org/10.1172/jci.insight.126967 PB - The American Society for Clinical Investigation ER -