[HTML][HTML] Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling
BS Hostager, IM Catlett, GA Bishop - Journal of Biological Chemistry, 2000 - ASBMB
Signals delivered to antigen-presenting cells through CD40 are critical for the activation of
immune responses. Intracellular tumor necrosis factor (TNF) receptor-associated factors
(TRAFs) are key elements of the signal transduction pathways of many TNF receptor family
members, including CD40. We show for the first time that engagement of CD40 in intact B
cells induces the rapid translocation of TRAF2 from the cytoplasm to the plasma membrane.
We found that CD40 engagement also results in its recruitment, together with TRAF2 and …
immune responses. Intracellular tumor necrosis factor (TNF) receptor-associated factors
(TRAFs) are key elements of the signal transduction pathways of many TNF receptor family
members, including CD40. We show for the first time that engagement of CD40 in intact B
cells induces the rapid translocation of TRAF2 from the cytoplasm to the plasma membrane.
We found that CD40 engagement also results in its recruitment, together with TRAF2 and …